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Category: Pharmacogenomics

Azathioprine Metabolism and PGx

Most commonly sold under the brand name Imuran, Azathioprine, an immunosuppressant, belongs to the drug class of thiopurines that works by suppressing blood cells that cause inflammation. Available in tablet form for oral administration, Imuran treats rheumatoid arthritis and some other inflammatory conditions. Each tablet contains 50mg Azathioprine and some inactive ingredients. As there are […]

How Long Does It Take for Ativan to Work? A Detailed Guide

Ativan, known generically as lorazepam, is a medication frequently prescribed for managing anxiety, insomnia, seizures, and muscle spasms. This drug belongs to the class of medication known as benzodiazepine that enhances the effects of a neurotransmitter called GABA (gamma-aminobutyric acid) in the brain. This promotes calmness, aids in sleep induction, and relaxes muscles. If you’ve […]

Allopurinol and Renal Function

High uric acid levels, also known as hyperuricemia, can be caused by a number of factors, including genetics, diet, medications, and other health conditions. High uric acid levels, also called hyperuricemia, can lead to several health problems, most notably gout (severe joint pain and inflammation), kidney stones, and potential complications related to cardiovascular health, including […]

CYP2D6 Ultrarapid Metabolizer Symptoms: Can Pharmacogenomics Help?

Cytochrome P450 2D6, commonly referred to as CYP2D6 is one of the key enzymes in the liver responsible for metabolizing approximately 25% of clinically used medications. Ultrarapid metabolizers have an increased rate of converting prodrugs, such as codeine and tramadol, into their active forms (morphine and O-desmethyltramadol, respectively). This rapid conversion can lead to a […]

Pharmacogenetics Test and ADHD

Attention-Deficit/Hyperactivity Disorder (ADHD) affects millions in the United States. According to the CDC, approximately 6 million children between the ages of 3–17 have been diagnosed with ADHD, while millions of adults also live with this condition. Treating ADHD effectively often involves trial and error with various medications and dosages, leading to prolonged discomfort for patients […]

Pharmacogenomics and Best Abemaciclib Dose (Verzenio)

Verzenio (abemaciclib) is a prescription medication used to treat advanced or metastatic breast cancer. Cancer cells grow and move to other organs, this medicine works by stopping the growth of cancer cells. It is a cyclin-dependent kinase (CDK) 4/6 inhibitor, meaning it blocks the activity of proteins that control cell growth, which can help slow […]

Pharmacogenomics Testing at Home

Most people are unaware of the fact that the FDA has labeled certain medications as they can affect individuals differently. Pharmacogenomics tests often known as PGx tests provide insights into your genetic makeup that help doctors tailor medications and reduce the trial-and-errors, especially in areas like mental health, where individual responses to drugs can vary […]

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