Introduction: Ever ask yourself why a drug works for one but is toxic for another? Thiopurine S-Methyltransferase (TPMT), or TPMT for short, is a crucial factor in the way our bodies metabolize certain drugs. We will discuss what TPMT testing is and how RPH Lab’s home PGx testing kit can potentially be part of the […]
CYP2D6 (Cytochrome P450 2D6) is a crucial liver enzyme responsible for metabolising approximately 25% of all clinically used drugs, including antidepressants, opioids, beta-blockers, and antipsychotics. Variations in CYP2D6 activity—due to genetic differences or CYP2D6 inhibitors—can significantly impact how medications are processed in the body. Real-World Example: Consider a patient prescribed codeine, a common pain reliever. […]
Derived from earthworms, particularly Lumbricus rubellus and Lumbricus bimastus, Lumbrokinase is a fibrinolytic enzyme. It can break down fibrinogen (a soluble plasma protein synthesised in the liver and becomes fibrin) and fibrin (an insoluble protein that stops bleeding and wound healing). Identified in 1991, this enzyme derived from earthworms has gained attention for its potential […]
Oncogenicity refers to a substance’s ability to activate genes that may cause cancer. This could involve pharmaceutical compounds, chemicals, or genetic changes. It increases the risk of tumor growth. This article explores oncogenicity, its role in ensuring safe medications, and the methods used to protect patients. This information is designed to help everyday people understand […]
A condition often referred to as a “histamine dumping,” occurs when there’s an excessive release of histamine (a naturally occurring compound involved in immune responses, digestion, sleep regulation, and even cardiovascular system) or when there is a deficiency of diamine oxidase (DAO), an enzyme that breaks down histamine. While histamine plays essential roles in the […]
To understand COMT Gene Mutation Supplements, it’s important to first know the COMT gene and its mutation. The COMT (catechol-O-methyltransferase) gene encodes an enzyme (COMT enzyme) responsible for breaking down catecholic compounds in the body, including neurotransmitters like dopamine, norepinephrine, and epinephrine, as well as hormones such as estrogen. By methylating (chemical process where a […]
The Pharmacogenetic Testing Costs vary based on the test complexity and insurance coverage. Some medications, especially mental health ones, have been indicated by the FDA to be administered based on genetic profile, which is commonly known as genome-based medication. Thus, depending on the issues an individual is experiencing, Medicare (Part B) and Medicaid may cover […]
Pharmacogenomic testing, also known as PGx testing, gives insights into your genetic makeup. In case of certain medications, this information is utilised to tailor treatments that have the least chance of trial and error. GeneSight testing is a branch of pharmacogenomic testing that assists healthcare providers in tailoring psychiatric treatments, such as depression, anxiety, ADHD, […]
Hormonal imbalances can significantly impact overall health, affecting everything from energy levels to mood and metabolism. The blood tests in this regard provide insights into hormone function, however, these tests require you to visit your healthcare specialist and are not non-invasive. The DUTCH testing, in comparison, has a different approach that offers a comprehensive analysis […]
Obsessive-Compulsive Disorder (OCD) and anxiety disorders are two of the most common mental health conditions in the United States. Although they share some similarities, they differ significantly in symptoms, causes, and treatment approaches. Anxiety disorders involve excessive worry, fear, or nervousness that interfere with daily life. Common types of anxiety disorders include Panic Disorder, Generalized […]